Bioreactors
Bioreactor and Fermentor with two Cultivation Vessels
The xCUBIO twin provides space- and resource-saving parallel operation in two vessels with just one single automation. Experiments can be done in steps while both vessels are perfectly split for aseptic conditions. Vessel geometry or equipment variations do allow comparative tests of two different approaches in the meantime. Scale-in-One-Design finally provides integrated scaling with internal inoculum production – fully automated!
Fermenters
SIP/CIP-Technology for High-end and Scaled Applications
The basis of xCUBIO enables bbi-biotech to supply qualified turn-key in-situ bioreactor installations for validated production processes after engineering, procurement, mounting and testing trials. We support the compilation of your necessary documentation.
Sampling & Handing
Bioreactor Sampling & Sample Handling
bbi-biotech supplies automatic sampling systems for all applications within biotechnology, pharmaceutical, food, cosmetics and chemical industry.
xCUBIO in-situ – 650 Liter Pilot Scale Fermenter
- Application: Agro-Biotechnology
- Customized engineering and design
- Fermenter-volume 650 l
- High-performance stirrer
- Air and oxygen feed via mass flow controllers, 4-fold cascaded oxygen control
- Mechanical foam desolator prepared
- Complete mechanical and process engineering
- Complete automation system with versatile sterilization sequences
Cell culture – Production on Highest Level
- Bioreactor operating volume 100 l
- Customized design
- Complete construction and engineering by bbi-biotech
- Complete automation system
- Gasmix unit with four mass flow controllers
- Split headspace and submerse gassing
- Automated sterilization
- Additional sequences for sub-functions (separate sterilization of fresh air, exhaust, sampling, emptying, harvest transfer, inoculum transfer)
- Delivery incl. bbi-biotech steam generator up to 40 kg steam per hour
xCUBIO phar – World’s smallest tubular glass photobioreactor
- Applications:
- Species screening
- Media- and process development
- Inoculum production
- 5 l overall volume, autoclavable in whole
- New system pump for scalable results
- Free choice of illumination type, wavelengths and sequences
- Implementation of flexible daylight cycles
- Multiple sensor installation, exhaust analysis
- Touchscreen automation with remote access
xCUBIO retrofit – Biostat C Upgrade and system summary
- Upgrade and refurbishment of an in-situ sterilizable fermenter
- 10 l steel vessel with accessories existing from the client
- System integrates external analytical devices und replaces broken control unit
- New stirrer, extended software access and centralized HMI
GE-Xcellerex – Automated with xCUBIO
- One-way-bag from multi-layer plastic foil
- Today: XDR-series with 50…2000 l cultivation volume per bag
- Addressed application field mainly cell cultivation in GMP environment
- xCUBIO automation during technology development
- Complete automation system for disposable sensors
Fermenter-Cascade with CIP/SIP-Cleaning
- Aerobic bacteria production
- Basic and detail engineering, delivery, assembly and start-up from just one hand!
- P&I-flow charts, 3D-engineering, calculation of all components, procurement, site management etc.
- Main fermenter 6500 l
- Inoculum fermenter 100 l
- Media vessels, acid, alkali, anti-foam
- Complete installation CIP/SIP-able
- Maximized gas feed rates
- Adaptation to existing building
- Complete automation with xCUBIO
- Fully automated operation with closed media
- Expansion with second main fermenter prepared